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ROC-Based Minimal Important Change

Source: R/mic_roc.R
mic_roc.Rd

Estimates the minimal important change (MIC) using receiver operating characteristic (ROC) analysis. The MIC is estimated as the change-score threshold that optimizes the Youden criterion.

Usage

mic_roc(
  data = NULL,
  x,
  y,
  tr,
  nboot = 0,
  report_every = 100,
  verbose = FALSE,
  max_attempts = nboot * 5
)

Arguments

data

Optional data frame containing the Time 1 score, Time 2 score, and binary anchor.

x

Numeric vector of scores at Time 1, or character name of the Time 1 score column in data.

y

Numeric vector of scores at Time 2, or character name of the Time 2 score column in data.

tr

Binary anchor vector, or character name of the anchor column in data. The anchor must be coded as 0/1 or TRUE/FALSE.

nboot

Integer. Number of bootstrap samples for estimating the 95% confidence interval. Bootstrapping is performed only when nboot >= 100.

report_every

Integer. The interval at which bootstrap progress should be printed.

verbose

Logical. If TRUE, progress messages are printed.

max_attempts

Integer. Maximum number of bootstrap attempts. This avoids an infinite loop when many bootstrap samples fail.

Value

A mic_roc object containing the ROC-based MIC and, optionally, bootstrap confidence intervals.

Details

Optional bootstrap confidence intervals can be requested by setting nboot >= 100.

For reproducible bootstrap confidence intervals, call set.seed() before calling mic_roc().

Examples

data(example)

nitems <- 10

example$score_t1 <- rowSums(example[, paste0("v1_", seq_len(nitems))])
example$score_t2 <- rowSums(example[, paste0("v2_", seq_len(nitems))])

mic_roc(
  data = example,
  x = "score_t1",
  y = "score_t2",
  tr = "trat",
  nboot = 0
)
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> ROC-based MIC estimation
#> ------------------------
#> MIC ROC: -0.500 

# \donttest{
set.seed(123)

mic_roc(
  data = example,
  x = "score_t1",
  y = "score_t2",
  tr = "trat",
  nboot = 500
)
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#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
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#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> Warning: 'transpose=TRUE' is deprecated. Only 'transpose=FALSE' will be allowed in a future version.
#> ROC-based MIC estimation
#> ------------------------
#> MIC ROC: -0.500 
#> Bootstrap 95% CI: -2.500 to 1.500 
#> Successful bootstrap estimates: 500 
# }